The HCGS includes a group of affiliated faculty who conduct research in areas that are enabled by genomics and bioinformatics. As a group these faculty are committed to the mission of the HCGS to support regional research and training activities in genomics and bioinformatics. The members represent diverse areas of expertise and significant infrastructure that can be leveraged to advance regional research programs.
This is accomplished by:
- Fostering interactions among scientists with shared interest thru weekly meetings and seminars
- Supporting the annual meeting of regional genomics faculty
- Providing guidance in shaping the future role of the HCGS
Plant breeding for a sustainable food system, novel crop development, identifying and characterizing genes controlling important agricultural traits.
The Cooper lab studies the mechanisms and dynamics of evolutionary adaptation in bacteria, particularly to novel hosts, as well the evolutionary interplay between the cell cycle and genome structure.
Major efforts involve gene-wide approaches toward environmental microbiology and host-microbe Interactions in symbiosis and pathogenesis
How does evolution proceed from common starting points and go on to generate the amazing display of biodiversity we see today? The evolutionary origins of novel and complex forms has puzzled biologists since before Darwin’s time and persists as one of the central questions in evolutionary biology. Research in my lab at UNH sheds light on this question by using the origins and evolution of the animal sensory systems as a model. Our approach integrates genomic, wet lab and behavioral data using phylogenetic methods. We are most interested in the sensory systems of Cnidaria, which are the evolutionary sister to bilaterians, and in those of other taxa that occupy key positions in the animal tree of life.
The MacManes lab strives to be the internationally recognized leader in the field of organismal biology and ecophysiological genomics. To accomplish this goal, we push ourselves to be careful in our observations, broad in our questions, and vigorous in our pursuit of research funding. We are generous in the dissemination our products - indeed, our vision of the future of Science is collaborative more so than competitive.
Our research focuses on how human activities are impacting terrestrial ecosystems, with an emphasis on soil biota and nutrient cycling processes. We are specifically interested in how anthropogenic stressors (e.g., climate change, nitrogen deposition, agricultural management, invasive species) affect the composition and diversity of soil microbial communities and microbial-mediated carbon and nitrogen cycles. We work at the interface between ecosystem science, microbial ecology and soil science, combining microbiological methods with stable isotope analysis and a variety of soil physical and chemical approaches to examine structure-function linkages.
The Culligan lab is focused on understanding the molecular mechanisms of cellular responses to DNA damage, employing genetic and genomic approaches in the model plant Arabidopsis thaliana.
Research in our lab is focused on the population ecology and conservation of vertebrates. We use interdisciplinary approaches, often integrating genetic and genomic tools with population and landscape modeling and the collection of observational and ecological data. We address fundamental and applied questions about animal dispersal, population structure and gene flow, ecological adaptation, and occupancy and abundance monitoring.
We use mass spectrometry-based proteomics approach to address complex biological questions, with an emphasis on the nature and function of posttranslational modifications and macromolecular recognitions on chromatin.
Uses genome-wide approaches to investigate the genetic basis of group formation and the epigenetic modifications involved with social phenotypes.
Research focus: The Cote laboratory uses both bioinformatics and proteomic approaches to study the structure, function, and regulation of the phosphodiesterase enzyme family for structure-aided drug design and for understanding the dynamic regulation of this enzyme family.
My research focuses on the regulation and engineering of interconnected cellular networks which govern the behavior of many subcellular systems, such as the protein secretion systems, the spore surface display system, and the formation of outer membrane vesicles. A combination of interdisciplinary approaches, encompassing synthetic biology, engineering design, comparative genomics, proteomics, biochemistry, molecular biology, and chemical biology, are used to investigate the interactions between components of these subcellular systems, discover the system-level mechanisms regulating these networks, and reprogram them for novel industrial and medical applications.
Dr. Kyle MacLea is an Assistant Professor of Biology at UNH Manchester where he teaches courses in the areas of molecular biology and microbiology. His research interests include prions and amyloids in yeast and human disease, microbial genetics, and the biology of molting and limb regeneration in decapod crustaceans (such as crabs, lobsters, and crayfish). A member of the Council on Undergraduate Research and the Genome Consortium for Active Teaching, Dr. MacLea is keenly interested in involving undergraduate biology students in authentic scientific research experiences, inside and outside of the classroom.
Cheryl P. Andam
Using an inter-disciplinary approach combining population genomics, phylogenetics and lab-based assays, I aim to identify the underlying mechanisms that govern population-level structure and dynamics of microbes in response to environmental perturbations and selective pressures. I am particularly interested in the process, mechanisms and impacts of horizontal gene transfer on the ecology, evolution and genome structure of microbes.
Jessica Ernakovich is a new faculty member in the Department of Natural Resources and the Environment. She investigates microbial communities, their functions, and physiology, with a particular interest in the linkages between community structure and biogeochemical processes. She is interested in microorganisms from a variety of ecosystems, and has worked previously with microorganisms surviving at the extremes, from frozen Arctic permafrost to the Australian Outback.